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Takashi Kojima Selected Research

Claudin-4

1/2019Induction of airway progenitor cells via p63 and KLF11 by Rho-kinase inhibitor Y27632 in hTERT-human nasal epithelial cells.
10/2017Regulation of claudin-4 via p63 in human epithelial cells.
1/2017The role of transcriptional factor p63 in regulation of epithelial barrier and ciliogenesis of human nasal epithelial cells.
6/2016Interferon-gamma increased epithelial barrier function via upregulating claudin-7 expression in human submandibular gland duct epithelium.
12/2015Claudin-4 binder C-CPE 194 enhances effects of anticancer agents on pancreatic cancer cell lines via a MAPK pathway.
3/2015Aberrant expression of claudin-4 and -7 in hepatocytes in the cirrhotic human liver.
12/2014Tight junction protein claudin-4 is modulated via ΔNp63 in human keratinocytes.
8/2014Targeting tight junctions during epithelial to mesenchymal transition in human pancreatic cancer.
9/2012Targeting claudin-4 in human pancreatic cancer.
8/2012Epidermal growth factor modulates claudins and tight junctional functions in ovarian cancer cell lines.
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Takashi Kojima Research Topics

Disease

89Neoplasms (Cancer)
11/2022 - 01/2002
42Esophageal Squamous Cell Carcinoma
11/2022 - 01/2011
35Esophageal Neoplasms (Esophageal Cancer)
10/2022 - 12/2007
29Dry Eye Syndromes (Dry Eye Syndrome)
01/2021 - 08/2003
21Stomach Neoplasms (Stomach Cancer)
07/2022 - 12/2003
16Squamous Cell Carcinoma (Epidermoid Carcinoma)
10/2022 - 01/2011
16Colorectal Neoplasms (Colorectal Cancer)
01/2022 - 06/2007
16Pancreatic Neoplasms (Pancreatic Cancer)
01/2020 - 08/2010
15Inflammation (Inflammations)
01/2022 - 01/2006
13Neoplasm Metastasis (Metastasis)
01/2022 - 05/2002
13Infections
02/2021 - 05/2002
12Adenocarcinoma
10/2022 - 01/2009
11Endometrial Neoplasms (Endometrial Cancer)
12/2021 - 11/2013
8Cataract (Cataracts)
01/2020 - 03/2004
7Disease Progression
08/2022 - 01/2009
7Allergic Rhinitis
08/2021 - 05/2005
7Carcinoma (Carcinomatosis)
07/2020 - 04/2003
7Respiratory Syncytial Virus Infections
01/2016 - 01/2011
6Carcinogenesis
05/2022 - 09/2006
5Retinal Detachment (Retinal Detachments)
03/2022 - 01/2017
5Myopia
01/2022 - 04/2008
5Squamous Cell Carcinoma of Head and Neck
01/2021 - 01/2012
5Proteinuria
01/2020 - 12/2009
4Keratoconus
01/2022 - 07/2013
4Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
01/2022 - 01/2006
4Sepsis (Septicemia)
01/2022 - 10/2010
4Wounds and Injuries (Trauma)
01/2022 - 01/2009
4Hypoxia (Hypoxemia)
01/2022 - 07/2011
4Neutropenia
01/2022 - 12/2019
4Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
06/2021 - 10/2016
4Retinal Perforations
05/2021 - 09/2010
4Febrile Neutropenia
02/2021 - 08/2011
4Astigmatism
10/2019 - 01/2008
4Fibrosis (Cirrhosis)
12/2018 - 05/2012
4Pathologic Constriction (Stenosis)
01/2018 - 01/2011
4Keratoconjunctivitis
11/2014 - 09/2008

Drug/Important Bio-Agent (IBA)

24Proteins (Proteins, Gene)FDA Link
11/2022 - 02/2003
23Fluorouracil (Carac)FDA LinkGeneric
01/2022 - 08/2002
22Tight Junction ProteinsIBA
12/2021 - 07/2003
19Cisplatin (Platino)FDA LinkGeneric
01/2022 - 12/2008
16Biomarkers (Surrogate Marker)IBA
11/2022 - 12/2011
16Claudin-4IBA
01/2019 - 12/2004
13CytokinesIBA
01/2022 - 01/2006
12Docetaxel (Taxotere)FDA Link
01/2022 - 11/2010
11Claudin-1IBA
11/2016 - 07/2003
10OccludinIBA
01/2020 - 12/2004
9NivolumabIBA
01/2022 - 01/2017
9ClaudinsIBA
12/2021 - 08/2006
9Ophthalmic Solutions (Eye Drops)IBA
05/2020 - 02/2005
9Pharmaceutical PreparationsIBA
01/2020 - 03/2008
8pembrolizumabIBA
10/2022 - 01/2019
8Lipoprotein Receptors (Lipoprotein Receptor)IBA
12/2021 - 05/2016
8MARVEL Domain Containing 2 ProteinIBA
08/2020 - 08/2011
8Messenger RNA (mRNA)IBA
01/2020 - 07/2011
7Immune Checkpoint InhibitorsIBA
09/2022 - 05/2017
7Monoclonal AntibodiesIBA
01/2021 - 07/2012
7Irinotecan (Camptosar)FDA LinkGeneric
12/2020 - 12/2008
6Histone Deacetylase InhibitorsIBA
05/2022 - 10/2007
6HMGB1 Protein (HMG1)IBA
01/2022 - 01/2020
6Fluorescein (Funduscein)FDA LinkGeneric
01/2021 - 11/2018
6Small Interfering RNA (siRNA)IBA
11/2020 - 09/2011
6diquafosolIBA
07/2020 - 07/2013
6Clostridium enterotoxinIBA
11/2013 - 09/2011
5AntigensIBA
11/2022 - 05/2005
5Glucose (Dextrose)FDA LinkGeneric
06/2022 - 02/2016
5regorafenibIBA
01/2022 - 12/2016
5trifluridine tipiracil drug combinationIBA
01/2022 - 01/2016
5PlatinumIBA
01/2022 - 01/2017
5Tretinoin (Retinoic Acid)FDA LinkGeneric
01/2016 - 01/2007
5Telomerase (Telomerase Reverse Transcriptase)IBA
11/2014 - 01/2011
4Histone Deacetylases (Histone Deacetylase)IBA
05/2022 - 01/2017
4Retinaldehyde (Retinal)IBA
03/2022 - 05/2007
4Indicators and Reagents (Reagents)IBA
11/2021 - 10/2010
4Bevacizumab (Avastin)FDA Link
01/2021 - 12/2009
4LigandsIBA
01/2021 - 02/2007
4LipidsIBA
01/2021 - 11/2003
4Paclitaxel (Taxol)FDA LinkGeneric
12/2020 - 01/2009
4SodiumIBA
07/2020 - 04/2018
4rebamipideIBA
08/2019 - 11/2013
4CreatinineIBA
10/2018 - 11/2016
4ErbB Receptors (EGF Receptor)IBA
04/2016 - 08/2012
4Phosphotransferases (Kinase)IBA
04/2016 - 07/2003
4InterferonsIBA
01/2016 - 01/2006
4Protein Kinase CIBA
08/2014 - 07/2011
4Thymic Stromal LymphopoietinIBA
01/2014 - 06/2012

Therapy/Procedure

52Therapeutics
11/2022 - 05/2007
38Drug Therapy (Chemotherapy)
10/2022 - 07/2007
23Chemoradiotherapy
08/2022 - 12/2007
11Esophagectomy
10/2022 - 10/2012
9Neoadjuvant Therapy
07/2020 - 08/2013
7Radiotherapy
04/2022 - 12/2016
6Aftercare (After-Treatment)
01/2021 - 10/2007
6Endoscopes
01/2021 - 10/2012
5Phakic Intraocular Lenses
01/2022 - 04/2012
5Immunotherapy
01/2022 - 07/2011
5Lasers (Laser)
07/2020 - 01/2008
4Laser In Situ Keratomileusis (LASIK)
04/2022 - 04/2008
4Lymph Node Excision (Lymph Node Dissection)
01/2022 - 01/2019
4Induction Chemotherapy
02/2021 - 07/2016
4Photochemotherapy (Photodynamic Therapy)
01/2020 - 09/2012